Primary structure of βs-crystallin from human lens
نویسندگان
چکیده
منابع مشابه
eye-lens protein y-crystallin
Although ubiquitous, no universal function can be confidently ascribed to glutathione. The eye lens maintains higher concentrations of reduced glutathione within its cells than do other tissues (Waley, 1969). The ratio of protein thiol to reduced glutathione in most species of lens is about 5:1 (Kuck et al., 1982). The requirement for glutathione in maintaining a transparent lens is indicated b...
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PURPOSE Lens alpha-crystallins, composed of two subunits of alphaA- and alphaB-crystallin, form low molecular weight (LMW) water soluble aggregates with an average molecular mass of approximately 800 kDa. In the intact lens, some of the alpha-crystallins are associated with even larger high-molecular-weight (HMW) aggregates which are thought to be precursors of components found in the water ins...
متن کاملLens differentiation. Crystallin synthesis in isolated epithelia from calf lenses
In the calf eye lens, four morphologically distinct cell types can be detected: three in the epithelial monolayer and one in the cortical part. During differentiation, there is a quantitative change in the synthesis of crystallin subunits. A marked increase in alphaA-chains and several beta-crystallin polypeptides accompanies the transition from epithelial to fiberlike lens cells while synthesi...
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BACKGROUND The eye lens is composed of fiber cells that are filled with α-, β- and γ-crystallins. The primary function of crystallins is to maintain the clarity of the lens through ordered interactions as well as through the chaperone-like function of α-crystallin. With aging, the chaperone function of α-crystallin decreases, with the concomitant accumulation of water-insoluble, light-scatterin...
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In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin. Abstract aA-crystallin and aB-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural proteins. Although numerous studies have examined their chaperone-like activities in vitro, little is known about the proteins they protect in vivo. To eluci...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1992
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2870375